ARP Rheumatology
ARP Rheumatology
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Clinical Practice

ARP Rheumatology Jan-Mar 2022; (1) 63-82
Clinical practice, rules or action protocols

Portuguese recommendations for the use of biological and targeted synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis – 2020 update

Authors

Fernandes BM, Guimarães F, Almeida DE, Neto A, Tavares-Costa J, Ribeiro AR, Quintal A, Pereira JP, Silva L, Nóvoa T, Faustino A, Vaz C, Khmelinskii N, Samões B, Dourado E, Silva J, Barcelos A, Mariz E, Guerra M, Santos MJ, Silvério-António M, Teixeira RL, Romão V, Santos H, Santos-Faria D, Azevedo S, Rodrigues A, Dias J, Lopes C, Pinto P, Couto M, Miranda L, Bernardo A, Cruz M, Teixeira F, Mourão AF, Neto A, Teixeira V, Cordeiro A, Barreira S, Inês L, Capela S, Sepriano A, Canhão H, Fonseca J, Duarte C, Bernardes M

Abstract

Objective: To update the recommendations for the treatment of rheumatoid arthritis (RA) with biological and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs), endorsed by the Portuguese Society of Rheumatology (SPR). Methods: These treatment recommendations were formulated by Portuguese rheumatologists taking into account previous recommendations, new literature evidence and consensus opinion. At a national meeting, in a virtual format, three of the ten previous recommendations were re-addressed and discussed after a more focused literature review. A first draft of the updated recommendations was elaborated by a team of SPR rheumatologists from the SPR rheumatoid arthritis study group, GEAR. The resulting document circulated among all SPR rheumatologists for discussion and input. The level of agreement with each of all the recommendations was anonymously voted online by all SPR rheumatologists. Results: These recommendations cover general aspects such as shared decision, treatment objectives, systematic assessment of disease activity and burden and its registry in Reuma.pt. Consensus was also achieved regarding specific aspects such as initiation of bDMARDs and tsDMARDs, assessment of treatment response, switching and definition of persistent remission. Conclusion: These recommendations may be used for guidance of treatment with bDMARDs and tsDMARDs in patients with RA. As more evidence becomes available and more therapies are licensed, these recommendations will be updated.

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Publication:

2021-09-23

Cite:

Bruno Miguel* Fernandes, Francisca* Guimarães, Diogo Esperança* Almeida, Agna* Neto, José Tavares-Costa, Ana Roxo Ribeiro, Alberto Quintal, Joaquim Polido Pereira, Lígia Silva, Teresa Nóvoa, Augusto Faustino, Cláudia Vaz, Nikita Khmelinskii, Beatriz Samões, Eduardo Dourado, Joana Silva, Anabela Barcelos, Eva Mariz, Miguel Guerra, Maria José Santos, Manuel Silvério-António, Rui Lourenço Teixeira, Vasco Romão, Helena Santos, Daniela Santos-Faria, Soraia Azevedo, Ana Rodrigues, João Dias, Carina Lopes, Patrícia Pinto, Maura Couto, Luís Miranda, Alexandra Bernardo, Margarida Cruz, Filipa Teixeira, Ana Filipa Mourão, Adriano Neto, Victor Teixeira, Ana Cordeiro, Sofia Barreira, Luís Inês, Susana Capela, Alexandre Sepriano, Helena Canhão, João Fonseca, Cátia$ Duarte, Miguel$ Bernardes. Portuguese recommendations for the use of biological and targeted synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis – 2020 update. ARP Rheumatology, Vol 1, nº1 2022:63-82
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