COVID-19 outcomes in hospitalized patients with underlying connective tissue disease-related interstitial lung disease vs. idiopathic interstitial pneumonia: a nationwide analysis 2019-2020
Authors
Husam El Sharu; Metri Haddaden; Sukhvir Singh; Maria Romero Noboa; Teeba Mubaydeen; Shehabaldin Alqalyoobie; Marwa Sabha;
Keywords
Background: In the context of the COVID-19 pandemic, understanding the influence of pre-existing Interstitial Lung Disease (ILD) on patient outcomes is crucial. This study aimed to compare the impact of COVID-19 on patients with Idiopathic Interstitial Pneumonia (IIP) versus Connective Tissue Disease-related ILD (CTD-ILD) in terms of mortality, length of hospital stay (LOS) and Intensive Care Unit (ICU) admission. Methods: The National Inpatient Sample (NIS) database for 2019-2020 identified adult patients hospitalized with COVID-19 and either IP or CTD-ILD. Patient demographics, comorbidities, and outcomes were analyzed. Results: Among 1,010,030 COVID-19 hospitalizations, 11,030 had ILD, with 1,105 associated with CTD. Although both IL and CTD-ILD groups had higher mortality rates than non-ILD patients, there was no significant difference in mortality between CTD-ILD and ILI groups. The odds ratio for mortality was 0.78 (95% CI 0.50-1.2, p = 0.3) for CTD-ILD compared to ILP patients and 1.54 (95% CI 1.03-2.31, p = 0.03) for CTD-ILD compared to non-ILD patients. Conclusion: This study underscores the importance of considering ILD subtypes in predicting COVID-19 outcomes. Despite demographic and comorbidity differences, mortality rates were comparable between CTD-ILD and IIP patients. Further research is needed to explore underlying mechanisms contributing to mortality in different ILD subtypes and the impact of specific rheumatological diseases and treatments on COVID-19 outcomes.
Husam El Sharu
East Carolina University
Metri Haddaden
The University of Oklahoma
Sukhvir Singh
East Carolina University
Maria Romero Noboa
University of Alabama at Birmingham
Teeba Mubaydeen
King Hussein Cancer Center
Shehabaldin Alqalyoobie
East Carolina University
Marwa Sabha
University Hospitals
East Carolina University
Metri Haddaden
The University of Oklahoma
Sukhvir Singh
East Carolina University
Maria Romero Noboa
University of Alabama at Birmingham
Teeba Mubaydeen
King Hussein Cancer Center
Shehabaldin Alqalyoobie
East Carolina University
Marwa Sabha
University Hospitals