Prevalence of Juvenile Fibromyalgia Syndrome in Turkish Patients with Juvenile Idiopathic Arthritis: A Multicenter Study
Authors
Gülcan Özomay Baykal; Semra Ayduran; Selen Duygu Arık; Ozge Baba; Serife Tunçez; Hafize Emine Sönmez; Kübra Öztürk; Semanur Özdel; Mukaddes Kalyoncu; Nuray Aktay Ayaz; Selçuk Yüksel; Betül Sözeri;
Keywords
OBJECTIVES: To investigate the diagnostic prevalence of juvenile fibromyalgia syndrome (JFMS) causing widespread pain in patients with a diagnosis of juvenile idiopathic arthritis (JIA).
METHODS: Patients with JIA from seven pediatric rheumatology centers in Türkiye were included. 2010 American College of Rheumatology criteria for fibromyalgia was utilized throughout a face-to-face interview. The Pain and Symptom Assessment Tool was used, and data were analyzed using the Widespread Pain Index and the Symptom Severity Scale. Patients were stratified into two groups: Group 1 (JIA with concomitant juvenile fibromyalgia) and Group 2 (JIA without juvenile fibromyalgia).
RESULTS: A total of 313 patients with JIA were included, of whom 21 (6.7%) were found to have concomitant JFMS. In group 1, 71% (15 patients) were female and 29% (6 patients) were male, with a median age at JFMS evaluation of 16 years (range: 12.8-19). Among patients with JFMS, 62% (13 patients) were classified as having spondyloarthropathy (enthesitis-related arthritis or juvenile psoriatic arthritis), 28.5% (6 patients) as having oligoarticular JIA, and 9.5% (2 patients) as having polyarticular JIA. Seventeen patients (81%) were on medication, including five (24%) on biologics. The most common symptoms in the JFMS group were muscle pain and fatigue, followed by headache, nervousness, numbness, dizziness, acne, abdominal pain, and anorexia.
CONCLUSION: In JIA patients with chronic musculoskeletal pain, fatigue, headache, and irritability lasting more than three months, the possible diagnosis of JFMS should be considered in the clinical evaluation.
Gülcan Özomay Baykal
University of Health Sciences, Ümraniye Training and Research Hospital
Semra Ayduran
Pamukkale University, Denizli, Turkey.
Selen Duygu Arık
İstanbul School of Medicine, İstanbul University, İstanbul, Turkey.
Ozge Baba
Karadeniz Technical University, Faculty of Medicine Trabzon, Turkey
Serife Tunçez
Ankara Etlik City Hospital, Ankara, Turkey.
Hafize Emine Sönmez
Kocaeli University,Faculty of Medicine, Kocaeli, Turkey.
Kübra Öztürk
Göztepe Prof. Dr. Süleyman Yalçın City Hospital, Istanbul, Turkey.
Semanur Özdel
Ankara Etlik City Hospital, Ankara, Turkey.
Mukaddes Kalyoncu
Karadeniz Technical University, Faculty of Medicine Trabzon, Turkey
Nuray Aktay Ayaz
İstanbul School of Medicine, İstanbul University, İstanbul, Turkey.
Selçuk Yüksel
Pamukkale University, Denizli, Turkey.
Betül Sözeri
Ümraniye Training and Research Hospital, Clinic of Pediatric Rheumatology,
University of Health Sciences, Ümraniye Training and Research Hospital
Semra Ayduran
Pamukkale University, Denizli, Turkey.
Selen Duygu Arık
İstanbul School of Medicine, İstanbul University, İstanbul, Turkey.
Ozge Baba
Karadeniz Technical University, Faculty of Medicine Trabzon, Turkey
Serife Tunçez
Ankara Etlik City Hospital, Ankara, Turkey.
Hafize Emine Sönmez
Kocaeli University,Faculty of Medicine, Kocaeli, Turkey.
Kübra Öztürk
Göztepe Prof. Dr. Süleyman Yalçın City Hospital, Istanbul, Turkey.
Semanur Özdel
Ankara Etlik City Hospital, Ankara, Turkey.
Mukaddes Kalyoncu
Karadeniz Technical University, Faculty of Medicine Trabzon, Turkey
Nuray Aktay Ayaz
İstanbul School of Medicine, İstanbul University, İstanbul, Turkey.
Selçuk Yüksel
Pamukkale University, Denizli, Turkey.
Betül Sözeri
Ümraniye Training and Research Hospital, Clinic of Pediatric Rheumatology,